WebAug 21, 2015 · As anticipated, peaks were identified in the vicinity of published YAP1 target genes, such as CTGF , CYR61 , NPPB , CCND1 , AXL , DKK1 , ITGB2 , WWC1 , and ANKRD1 (Fig 1C and S3 Fig). Although ANKRD1 expression is commonly used to monitor YAP1 transcriptional activity, to our knowledge, it has not formerly been proven as a … WebFeb 1, 2024 · Additionally, SREBP1-overexpressing 8505C and K1 cells were transfected with control siRNA or siRNA targeting CYR61 or CTGF. CYR61 or CTGF silencing mitigated SREBP1-facilitated invasiveness . Taken together, the promotion of invasive phenotypes by SREBP1 was, at least in part, mediated by CYR61/CTGF via the Hippo-YAP pathway.
Entry - *602369 - CELLULAR COMMUNICATION NETWORK FACTOR 1; CCN1 …
WebJan 8, 2024 · CTGF or CYR61 were neutralized by the addition of antibodies at the indicated concentration to the culture medium when cells were seeded. (A–C) In co-cultures of 6x YAP5SA: 1x nuclear mCherry expressing cells (n-mCherry), CTGF neutralization increases the n-mCherry cells’ carrying capacity ... http://www.worldjour.net/Article/show/id/184.html epwired
Frontiers Endothelial YAP/TAZ Signaling in Angiogenesis and …
WebJan 21, 2024 · As expected, YAP nuclear localization (Figures 7 C and 7D) and transcription of CYR61 and CTGF were increased in cells that had experienced shear stress (Figure 7 E). The induction of the YAP/TAZ target CYR61 upon flow is therefore a suitable assay to study the shear-stress-mediated regulation of the Hippo pathway. To examine whether the ... WebCYR61, CTGF and ANKRD1 are the most well-known downstream targets of YAP1 [6,7]. Despite numerous observations that the Hippo pathway is involved in various cancers [ 8 ], its role in the development and progression of GBM has not been properly addressed, and the clinical significance of the inactivation of the Hippo pathway has not been fully ... WebApr 12, 2024 · Intracavernosal pressure/mean arterial pressure (ICP/MAP) was measured 14 and 28 days after treatment. Penile tissue specimens were collected for pathological examination, and the changes in YAP, TAZ, CTGF, CYR61, LATS1, and p38 MAPK expression levels were assessed by Western blot, RT–qPCR and immunological … epw interpolation